How are you burning the iso? Are you burning from Windows or linux? And what program are you using to burn the disk?
If you are burning from Windows try Iso Recorder or Infra Recorder:
Burn at the slowest speed and check the md5sums. I used Iso Recorder on Windows XP the first time I installed Ubuntu (3.5 years ago) and it worked well.
Perhaps you just downloaded a corrupt copy of Ubuntu Studio. Try downloading from a different mirror if possible.
You could just download and burn a copy of Ubuntu 8.10 and install the Ubuntu Studio multimedia packages and you will end up with the same thing. See this:
And welcome to the LQ forums!