There's a lot you can do. Basically you have to tell your system where is the wacom tablet (try with setserial /dev/ttyS0 port 0x06f8 irq 6 autoconfig). At this point, check if it works with wacdump -f c100 /dev/ttyS0.
I have a C112, debian powered, and I didn't manage to make it work yet. I suppose there's a little mess under here, 'cause my linuxtells me there no serial at that I/O ( but there is, really, I made it work with Suse once).
In any case, there's a good thread at