I use Ardour as a DAW with 12.1. The build used to be difficult but I found the packages from the Slakcy site
to be quite complete. I just used Gslapt and it added the dependencies and installed correctly. Which was quite a surprise considering in the past it was a little annoying tracking down all the libraries.
As an aside Slack is a good choice for a DAW, as I ran side by side comparisons with Ubuntu Studio and JackLab (OpenSuse) and an Ardour/DAW Slack on identical build boxes. I then ran the same dance beat 12 track mix through them and checked which one started degrading first upon identical mods of the tracks. Slackware came out first in being to handle the tracks properly, accurately and under the heaviest load. I also used Ardour with OS X (Tiger) on a similar spec'd Mac Mini in the test, it came in last by a long shot.