Well, I know that with games that use SDL, if you are using the evdev driver, the mouse will not respond unless you have this in your '/etc/X11/xorg.conf':
Code:
Section "Module"
SubSection "extmod"
Option "omit xfree86-dga" # don't initialise the DGA extension
EndSubSection
EndSection
If that section exists, just add the subsection stuff to it.