My mouse pointer does not always configure correctly with acceleration not working at all. Restarting X does not resolve the problem. Only a full reboot resolves the problem.
Without acceleration, moving the mouse pointer is like pushing peanuts.
At one time the problem occurred about once a month, so about once every 30 to 50 reboots. Lately the problem seems to occur about once every 5 reboots.
I have been unable to pinpoint any cause or reason.
The mouse is a generic Microsoft optical device, appearing in lsusb as:
Bus 002 Device 003: ID 045e:0040 Microsoft Corp. Wheel Mouse Optical
I haven't tested a different mouse.
I appreciate any thoughts or ideas.