OK, hope you still read this thread, I just found how to solve it -- if you run gentoo hardened, that is.
Head over to the wine folder (/usr/lib/wine/bin or something) and do
chpax -pemrxs wine wineserver winepreloader
"paxctl" can also be used if you have that installed.
This will disable all hardened-restrictions on wine.
There are probably some flags that could remain turned on, play around a bit to find the "most secure" situation that still works.