Welcome to LQ!
There are many options for usb and linux
now, I assume you mean a fat32 usb or ext3 usb?
syslinux or grub?
how much do you know about Linux
and please give specs on usb and your computer
Now, it's easy to hook it up to boot many, many distro's
I have about 8-10 on mine at any one time
all are frugal persistent too
so, what distro's you wanna put on the Stick?