Do whatever you like
I use Wine for a couple of games, and some other Windows software that is, to me, absolutely irreplacable (such as Buzz
). It can be a minor headache at times, but generally, once it's configured properly, it runs without incident. If anything crashes, at least you can be fairly certain it won't take your whole operating system (or your whole network) down along with it!
I know of no software made by Microsoft that does not have a better free/OSS replacement, with the possible exception of Access (which still has no counterpart in OpenOffice) - but if you're serious about database work, there are several far more powerful database systems, such as MySQL and PostGreSQL; if you're just tinkering with databases, there are a lot of special-purpose simplified databases available also. For anything else in the MS Office suite, OpenOffice or KOffice are perfectly adequate. Name anything else MS makes and I bet you could find three or four better free/OSS packages to replace it.