to be honest i know very little about wine, as i steer clear of it. there's a config program called wine-setup i think, which sets up various defaults for you, but someone else with more wine knowledge will be able to help. also there's a site, franks corner, dedicated to wine.
if you are on Fc5 then the livna repo's on yum contain the compiled nvidia drivers. i appreciate that that might sound like gibberish to you though :-s check this: http://rpm.livna.org/configuration.html#Core5
and follow the details there. once done just do this: http://rpm.livna.org/livna-switcher.html
and you're done. people do have a lot of problems with ati and nvidia cards, but this is a doddle this way.