1. You can delete them if they're not being used. of course, if they were installed via a package manager such as RPM, you should use that package manager to remove them. Some software will have a make uninstall, if you retained the source tree.
2. Hmmm ... I don't think so, since a library could be used by a program that's not executing at the moment. One way to try and do this would be to run ldd on all your binaries and see if any libraries don't show up. I doubt it's worth the effort, though.
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