They are really good open source tools for network/system monitoring. However, no matter how good the tool is, it's useless without a skilled analyst.
Just because you have a large network, it doesn't mean you have to monitor all of it. Some monitoring is better than none. You're going to need to determine which computers need monitoring the most and have the analysts to analyze all of the data the tools generate.
If I were you, I'd start off small and work my way up. For example, I wouldn't use Argus, I'd start with what you already have in place such as NetFlow enabled on select routers and use flow-tools for collecting and analysis of the flows. I've just started reading
Network Flow Analysis which is pretty good so far.
OSSEC Host-Based Intrusion Detection Guide is a good book on OSSEC, and
Snort IDS and IPS Toolkit is a good book on Snort.