At linuxgames.com you can find a guide in setting up wine.
But to the best of my knowlegde, you can get Flash for Linux
Or else you could visit http://www.winehq.com
which is the wine projects official homepage, there you can find some more info/support
wine can use some of the windowz dll's so if you have windowz intalled on the same comp. as you'r running Linux on, you can set wine up to run with thise native windowz dll's by editing you'r /etc/wine/wine.conf (or it is located in) /etc/wine.conf (depending of which version of wine you'r using)
I have never tried to run serious programs with wine, only games like Star Craft, Blade Runner and Red Alert and they have all been running ok
well hope this could help you a bit