What exactly do you mean by supercomputer?
I'm pretty sure if you want to play games for windows you should consider using Cedega
For someone new to linux I would not recommend gentoo, however that's what the gamers that I know run (gentoo+cedega). Nvidia seems to have the best *nix support from what I hear and have seen.
I have heard various results of success with wine. I haven't fooled with it much yet personally but it seems to be the default option. that's why I asked about what was meant by 'supercomputer'. For example if you had a game that ran at 100fps on your windows machine, would emulating windows drop the performance to an unacceptable rate? I don't think it will, can someone confirm? Like I said I don't have personal experience but this is what I have heard. Conversely, if you have a game that plays @ 30fps on your windows box it would be useless to try to emulate it. Again asking for confirmation but pretty sure.
I thought fedora was pretty easy to learn and is easy to manage. I checked out a book on it @ the library and was up and running very quickly.