AwesomeMachine: yea.... thats like tossing your bread in the sun, when a toaster works just fine.
Vmware is a bit much, especially if a program you want to run actually works in wine, pluses, no extra baggage associated with running multiple OS's, plus, no need to pay for something thats essentially worthless to any home user.
Using wine is simple, as already said, its simple:
where path/to/windows/executable.exe is the windows .exe to run. It requires a bit of work it initially setup, and some programs might seem buggy (and every program will be very ugly, this is a windows look-alike after all, not some GTK or QT work of art). Use
to setup wine, the hardest part is the drives, like windows, these dialogs arnt very intuitive, so expect a bit of pain, but once you have the drives all setup properly, everything else is fairly easy... assuming the program works.