I don't think so, though I haven't tried it.
The primary difference I have seen between Netbook Remix and standard Ubuntu is the selection of programs installed. For example, for Open Office (LibreOffice), Calc, Writer, and Impress are installed, rather than the full suite. In terms of load on your processor, what matters is what is actually running, not what's installed on the hard drive.
I have found that certain resource-intensive programs, such as Google Earth, don't seem to like Atom processors and won't work properly.