All Epson scanners should be supported at a basic level by the sane epson2 backend. For full support though you'll need to use the proprietary (and pretty lousy) avasys iscan and it's accompanying epkowa backend.
If you want real power, consider purchasing vuescan. It's got lots of nice features.
Links are in my signature.
Last edited by David the H.; 08-05-2010 at 03:28 PM.
Reason: edited for clarity