An area of my ignorance I confess, but I believe there has been some limited succes in this area. A quick google brought up www.frankscorner.org
which reports which games will run under wine.
But if you are serious about this you might want to look at Cedega - a commercial, subscription-based version of Wine especially for gaming. It is (in linux terms) a costly proposition but it is your best option if you want PC gaming with high profile titles under linux.