Well there is freedos:
and you don't even need linux! There is also dosemu:
which runs on linux. There is also a linux interpreter for those great games like Day of the Tentacle and Sam n Max, who's name escapes me, but shouldn't be hard to find.
Haven't used any of these myself, except for the interpreter, which was not quite 100% last time I looked. In particular I don't know how well they handle graphics and sound. It would be nice to see some comments on that.