if you are trying to run ms-dos applications you may consider using DosBox, it is available at no charge.
Regarding wine, after installing wine use this command:
$ wine [path to the setup file]
this will run your installer.
There is no assurance that your application will run trouble free in wine. In case of a problem try visiting www.winehq.org
One more thing, your wine directory is located in $HOME/.winr (eg. /home/[user name]/.wine or whatever it is for you)
and programs are installed in $HOME/.wine/drive_c/Program Files/
To run your installed program you can either use the wine menu in the desktop(if you have it) or use
$wine [path to the executable]
the executable most likely can be found in /home/[user name]/.wine/drive_c/Program Files/[Application Name]/
You can also change wine configuration using
Regarding DosBox, there is a Linux version of the application, use it if you manage to resolve the dependencies,
else you can try running DosBox using Wine.
There are many things you may need to know about wine, try going through the User Guide(available in the wine website).