Adjusting the monitor is the right way.
The size of the picture on your monitor (Cathode Ray monitor, not LCD display) is the right way to use your full screen.
Monitors do store a setting for each combination of resolution, colors, and other factors. So when you are using a new resolution, you have to adjust the position, with, height and pincushion, etc. for a single time.
I'd stick with the resolutin that does not appear to flickr (refresh rate in Hz) and does make you read comforatble.