I've used Mint on several computers and never encountered anything of this nature and have never heard of anything called "blind registration" (that's not to say it doesn't exist, but a web search for "blind registration" linux turns up nothing).
The first thing to do is to rule out hardware as the cause of the problem, as no amount of software troubleshooting in world will fix a hardware problem. Here are some tests you can run:
The next time this happens, try unplugging the devices and plugging them back in. If they don't work in the same ports, try different ports.
If you have another keyboard and mouse or can borrow them from a friend for testing purposes, try swapping them out to see whether the problem persists through enough reboots to give you grounds for a reasonable conclusion.
Boot to a Live CD of something that's not Mint or Ubuntu-based and see whether the problem occurs with it.
If that doesn't help, try providing additional information as suggested by pan64. The more information you provide, the easier it is for others to help you.
Last edited by frankbell; 05-26-2015 at 08:48 PM.