Certainly - if the modprobe doesn't work then post the output of your lsmod and highlight the module you are having the problem with i should be able to tell, some are obvious from their name others require a bit of digging around. eg. on my system if i had the problem trying to remove the ip_tables module (for example) :
ip_tables 21953 4 iptable_raw,iptable_mangle,iptable_nat,iptable_filter
I would run:
modprobe -r ip_tables
Hope this makes sense, usually the modprobe -r removes the module and its dependants.