How to uninstall a Program without rpm or yum
well one should always build for there package manager. but usually it pretty simple download the source and read the reame and the install. 90 percent of the time from a terminal you will run ./configure then make then make install. then make uninstall. and many of these programs may have a make spec file for rpm etc etc.
your question should be how do I uninstall wine on a rpm system. you use the package manager locate wine and select uninstall.
as far as wine goes. and rpm command line would look like this
rpm -evv wine The -e (erase) option is used to remove package.
here is a nice help page on yum command line
I would suggest not to manually delete stuff that has been installed by a package manager. If you have already installed with a package manager and went in and deleted stuff re-install it then uninstall it. hopefully you did not break anything.
you may want to check and see if you have cross over installed for some other programs this will do this.
rm /usr/bin/wine if you really hate that much.