I have tried several versions/flavors of Linux. I liked Mandrake 9.x, but 10.x froze my computer and I have not successfully managed to install anything since they merged with Connectiva to form Mandriva. I had a really nice installation of SuSE not that long ago... but then I ran into Ubuntu. It may not be for the hardened Linux user, but it's great for we who have not yet let go of Windoze and the fact that it loads easily and runs and looks good. I'm using Ubuntu 8.04 Hardy Heron -- hint, get Gnome, not KDE, if you want the system to run quickly.
These comments are my own and do not reflect the opinions of this station or any other semi-sentient being.
As for your original question, it seems that many have succeeded in getting MS Office to run under Wine... I haven't yet, in fact that is why I was just now searching this forum. When I can get that to happen, I will be done with Windoze altogether -- sadly, there are bugs or incomplete programming in OpenOffice.org (all reported, none fully fixed) which prevents me from using OOo in my work as a professional editor.