you mean to configure source code? like you've downloaded a new package and want to compile it?
for the most part you dont really need to anything other than ./configure, make, make install I don't know that there is a graphical mode, just open a terminal window unpack the tar or bz2 file and away you go...
If your using Red Hat though, you might want to try and find an RPM for the program instead of using source code. RPMs are easier to install and are designed to work with RH. You can use GUI RPM managers like xrpm to install them too.
Hope that helps some