I would stick to a distro that is set up for audio, like ubuntu studio. Linux's kernel isn't real time, which some audio applications can't do without. Ubuntu studio uses a low latency kernel, not the stock linux kernel. Other distro's set up specifically for audio processing will use a custom kernel as well. I'm sure there are a few other distro's set up just for audio processing, but as I'm not an audiophile, I have no idea what they are.
The ubuntu's have a reputation of not only being easy to use, but also having very newbie friendly communities. I use Kubuntu myself, and have received quite a bit of help.
Best of luck...