If you can get mt to work with the tape drive, then Amanda will work with it. Find the right device, perhaps st0. Then if you can do things like `mt -f /dev/nst0 status`, etc., you should be ok.
Get an Amanda distribution or source and install it. Then use `amtapetype -f /dev/nst0` to run it through its paces and check the performance. That will take quite a while, because it writes the whole tape once or twice, but it makes sure it works and determines the tape size and performance on your system. You need to make sure you have compression turned off on the tape drive and a new tape.
One issue with the faster drives of recent years is that you really have to have your computer properly configured and tuned to keep up with the tape drive. If you have a desktop machine with a shared bus for drives and other cost cutting designs, you may have issues with pulling data fast enough to push the drive. A server will be designed and configured to be able to maintain the data transfer speeds.