Yeah, AFAIK its possible to run 1 monitor rotated and others in standard format with the nVidia closed drivers.
However, I've got to warn you off the NVS 420- they are crap. 2 x 8400GS GPUs, and the 8400GS is known to have issues. Dont get a quadro card at all unless you want to use professional 3D graphics (e.g. 3D studio max). Get a GT6XX card instead. Cheaper, faster, supports 4 monitors. I'd be checking the specs carefully on any GT6XX card you might think about getting though, some of them only support 2-3 monitors.
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