There are several ways to do this, but the "grass roots" way (generally distro-independent) is as follows.
Switch to a console (CTRL-ALT-F3 etc.) or boot into rescue mode, and log in as root. Then edit your /etc/X11/Xorg.conf (or XF86Config-4), and change the mouse location from /dev/ttyS0 to /dev/mouse, and the protocol to "auto". I.e., you should now have an entry such as
Code:
Section "InputDevice"
Identifier "PS/2 Mouse"
Driver "mouse"
Option "Protocol" "auto"
# Option "ZAxisMapping" "4 5"
Option "Device" "/dev/mouse"
Option "Emulate3Buttons" "true"
Option "Emulate3Timeout" "70"
Option "SendCoreEvents" "true"
EndSection
You'll also need to uncomment out the ZAxisMapping line if you have a wheel mouse, if it hasn't already been done.
Good luck
mj
EDIT: You'll probably also want to leave the "Identifier" line as it already was - either that or change it also to PS/2 Mouse in the "Server Layout" section (usually either at the beginning or end of the config file).