The title is a little unclear: I'm thinking this.

A Supercomputing cluster running a linux OS would have, say, 100 nodes. The hub (I think that's the term) would be running Gnome, KDE, or some other desktop gui. Any vital programs would also be running from the hub. Any other processes, however, would be delegated to a hub, much like individual cores in a multi-core tower. That way, you could be running 500+ intensive programs, relative to the nodes' power, and they would all run perfectly smoothly.

Am I crazy, or is there some way to do it?

i believe the term is 'controller' node, and i would imagine that it can run some sort of gui, not all programs that take advantage of a cluster run from a command line.