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As far as I know, every directory that's contained in /lib/modules corresponds to a different kernel, and they should all be independent, so you could safely remove them.
Did you install them manually (make config, make deps, etc) or did you install them as a package with rpm, dpkg or whatever? If you installed them precompiled, I would deinstall them in the same way.
If you are not really sure to delete them, you can rename them (mv 2.4.18-18.7.xdebug 2.4.18-18.7.xdebug.old).
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