I don't know the optimal filesystem, but the main concern with flash memory is the aging due to writing.
To minimize disc writes you should pick a system that does not use journaling, although you may suffer loss if it isn't properly unmounted. Also make sure the disc is mounted using the 'noatime' and 'nodiratime' options so that it won't update access times for files and directories.
Most if not all filesystems for linux tries to spread files across the storage surface to minimize file fragmentation so that would also help to even out the tear and wear of writing.
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