Sorry. I should've provided more details. Essentially, up2date fails with:
There was a fatal error communicating with the server. The message was:
An HTTP error occurred:
Status Code: 403
Error Message: Forbidden
First, I can get to this site via my browser & know that it is accesble. Also, this doesn't make since the policy on the ISA server is pretty much wide open to all sites & all ports. I guess the next step is to get a trace & see who is dropping the connection.