I think there is device contention between your host OS and your guest OS; in QEMU, you must input the explicit command to change the optical disc (or iso image) in the Qemu Monitor, which is accessible by pressing Ctrl-Alt-2. See the syntax here:
http://bellard.org/qemu/qemu-doc.html#SEC12.
Since KVM is based hugely on QEMU, this may work for you too. Just don't forget to get back into your guest OS by pressing Ctrl-Alt-1 when you're done