If I read this right you're actually asking if you can run PowerBuilder under wine on Linux rather than just run it on Linux. Not having used this I had a look at it and it appears to be a Windows only product so you'd have to install it under a Windows emulator like wine.
However it seems you would be making your life rather complicated by trying to run Sybase products in Windows fashion when they actually have Linux ports for several products. Also it seems highly likely Sybase wouldn't consider wine installations "supportable".
I'd suggest you check out the following link:
It gives you a list of products Sybase supports under Linux. It looks like they have another tool for building applications for Linux that's not called PowerBuilder.