A newer category that has been quite close since its inception.

--jeremy

CherryPy

Django but I also like CherryPy or web2py

Would Twitter Bootstrap be under consideration in this category? Its a great toolkit, but I'm thinking its a bit of a stretch to call it a "framework".

My vote is for Yii

I've been using Flask this year and I'm loving it. Small, yet powerful, has clean API and is easily extendable by a numerous list of extensions. It also is very agnostic about the choices I make and allows me to use best of breed tools, e.g. SQLAlchemy for relational databases. I really hope that Flask will get a wider recognition, it deserves this.

Clashed with some JS Frameworks Mojo,jquery and etc for fx effects,UI this year..
It was horrible performance spikes, required a deep code knowledge/bughunt of used framework and it's work on different sw platforms.
Voted for none,got headaches even from old jquery.

Django. To get an idea of how perfect Django is, consider that competing Python web frameworks such as Web2Py, Flask and Bottle try to distinguish themselves from Django not by having more features and doing more, but by being more streamlined and doing less.

Well said.

Disclaimer: I haven't used Django and only talk about it form what I've read and code examples I've seen. So if I'm wrong, feel free to correct me. Thanks.

There's a reason why frameworks like Flask are advertising themselves as small. You get a well written core and ability to build upon it whatever you want or need. The whole system in this case is loosely coupled, and that's a very big advantage in my view. Yes, Django does more out of the box, but its components are tightly coupled and once you try to switch some of them to anything else (let's say, Django ORM to SQLAlchemy), suddenly you start losing functionality in many places.

You are not wrong and 100% of what you've written is correct.

I have been using QCubed for sometime now. Its based on Qcodo users who were tired with non development of Qcodo. Give it a try

My vote is for Ruby on rails, though I am still learning it.

Have a look at brython: http://code.google.com/p/brython/