There is only one issue with this board that I can tell as far as Linux goes. The hardware sensor chip is a bit iffy with Linux. I guess it can be set up, but its a lot of work, requiring a kernel recompile.
On a purely hardware issue, you may find some of these boards to be unstable. Mine was so bad that it would hard lock whenever it was under any load at all. I solved it with the soldering fix ar the Asus Reworking Guide. If you have one of these boards and its locking up, go there and fix it. You'll have a super solid board after that.
EDIT: Regarding the rework - I have also written down what I did to fix my board
HERE as well.
